【Objective】The present experiment was conducted to investigate optimum environmental conditions for growth and development of Amusium pleuronectes larvae， in order to provide reference for large-scale propagation and genetic resources conservation of A. pleuronectes. 【Method】The effects of salinity and pH on survival and growth of A. pleuronectes straight-hinged larvae were studied under the controlled conditions. And the optimal salinity and pH for survival and growth were defined through two-point method and regression analysis. 【Result】The results showed that the salinity and pH had significant effects on survival and growth of straight-hinged A. pleuronectes larval（P＜0.05）. The suitable salinity for survival was 23.20‰-38.02‰， and the optimal salinity was 25.00‰-35.00‰. The suitable salinity for growth was 22.53‰-37.99‰， and the optimal salinity was 25.00‰-35.00‰. In addition， the suitable pH for survival was 6.8-8.8， the optimal pH was 7.0-8.5， and the suitable pH for growth was 6.3-8.6， and the optimal pH was 7.5-8.5. 【Conclusion】The tolerance to low salinity for A. pleuronectes straight-hinged larvae is not strong enough， thus the nursery for rearing larvae should be near coast with 25.00‰-35.00‰ salinity， and it is necessary to maintain optimum salinity for survival and growth， so as to prevent salinity and pH from declining sharply.