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中药治疗奶牛乳房炎的系统评价与Meta分析
作者: 杨 健1  2  严作廷1  王东升1  张世栋1  杨志强1  董书伟1 *  
单位: (1 中国农业科学院 兰州畜牧与兽药研究所/农业部兽用药物创制重点实验室/甘肃省新兽药工程重点实验室  
关键词: 奶牛  乳房炎  Meta分析  中药  青链霉素  
分类号:S858.232.6
出版年,卷(期):页码:2016 ,47 ( 4 ): 页码:656-663
摘要:

【目的】利用Meta分析方法对已发表的中药治疗奶牛乳房炎临床试验研究进行系统评价,为防治奶牛乳房炎提供更有价值的参考依据。【方法】通过计算机检索中国知网(CNKI)和万方数据库,检索时限均为从建库起至2015年4月,全面收集中药治疗奶牛乳房炎的临床试验研究。按照Cochrane方法纳入文献,采用RevMan 5.3软件进行Meta分析。【结果】共纳入26篇文献,3419头患病牛,其中试验组2481例,对照组938例,试验组均采用中药治疗,对照组采用青链霉素治疗。复方中药治疗牛乳房炎的总治愈率显著高于青链霉素对照组[OR=2.03,95% CI(1.56,2.63),P<0.05],总有效率显著高于青链霉素对照组[OR=2.25,95% CI(1.57,3.22),P<0.05],乳区总治愈率高于青链霉素对照组[OR=1.54,95% CI(1.43,1.66),P<0.05],乳区总有效率极显著高于青链霉素对照组[OR=1.20,95% CI(1.15,1.26),P<0.01]。发表偏倚分析结果显示,所纳入文献存在一定的发表偏倚性。【结论】复方中药对奶牛乳房炎的疗效显著优于青链霉素,即奶牛乳房炎的中药防治研究存在重要潜力。

【Objective】The published clinical trial about treatment of cow mastitis with Chinese herbal medicine were systemically evaluated by meta-analysis method, in order to provide valuable reference for treatment of cow mastitis. 【Method】The clinical randomised controlled trials(RCTs) about treatment of cow mastitis with Chinese herbal medicine were searched completely from databases of CNKI and WANFANG DATA. According to Cochrane system instruction, meta-analysis was conducted by using RevMan 5.3 software. 【Result】A total of 26 RCTs and 3419 diseased cows were included, among them, 2481 cows in treatment group treated with Chinese herbal medicine, 938 cows in control group treated with penicillin-stretomycin. In addition, The cure rate of total cow number in Chinese herbal medicine group was significantly higher than that in penicillin-stretomycin group[OR=2.03, 95% CI(1.56, 2.63), P<0.05]. The effective rate of total cows number in Chinese herbal medicine group was significantly higher than that in penicillin-stretomycin group[OR=2.25, 95% CI(1.57,3.22), P<0.05]. The cure rate of total breast area number in Chinese herbal medicine group was higher than that in penicillin-stretomycin group[OR=1.54, 95% CI(1.43, 1.66), P<0.05]. The effective rate of total breast area number in Chinese herbal medicine group was higher than that in penicillin-stretomycin group[OR=1.20, 95% CI(1.15, 1.26), P<0.01]. The analysis results of publication bias showed that the included literatures had some certain bias. 【Conclusion】Chinese herbal medicine has more significant curative effect on cow mastitis than penicillin-streptomycin.

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