【Objective】Genetic analysis of resistance to sheath blight was analyzed in resistance sources of ZD 304，MR1400， T1006 and DQ50 to provide references for gene mapping and breeding. 【Method】Four indica rice resistance sources ZD304， MR1400，T1006 and DQ50 （male parent） were crossed with japonica rice ZY1211 （female parent） which was highly susceptible to sheath blight to get F1 and F2 used for genetic analysis by using toothpick embedding inoculation method with Guangxi prevailing strain AG-I-IA and GX-2. 【Result】ZD 304，MR1400， T1006 and DQ50 were moderately susceptible to sheath blight. ZY1211 was highly susceptible to sheath blight. The resistances of F1 in the 4 cross combinations were 4.0-8.0（M-HS） grade with the average grade of 5.1-6.1. The population resistance showed continuous distribution. The F2 population segregated greatly and showed continuous unimodal distribution with the grade of 2.0-9.0 （R-HS）. Among the resistance resources， the resistance heritability of ZD304， MR1400， T1006 and DQ50 was 15.4%， 31.1%， 47.7% and 43.8%，respectively. 【Conclusion】Resistance of ZD304， MR1400， T1006 and DQ50 to sheath blight was quantitative trait and controlled by micro-multiple genes， and the resistances of F1 popuations in the 4 cross combinations were between their parents.