【Objective】In order to provide scientific basis for drip irrigation fertilization method in sweet-waxy maize，the research was conducted to analyze the effects of fertilizer application，application period and ratio on substance accumulation，yield and quality of sweet-waxy maize under the drip irrigation. 【Method】Under field experiment， the different treatments of 50%-100% fertilizer compared to the contrast on the basis of NPK’s basic fertilizer：seeding fertilizer：jointing stage fertilizer：panicle fertilizer=3∶1∶3∶3，6∶1∶2∶1，3∶3∶2∶2，were set to determine the sweet-waxy maize yield，substance accumulation，soluble sugar，starch and protein. 【Result】The results showed that drip irrigation fertilization（reducing by 10%-50% fertilizer compared to the contrast） had no obvious influence on ear length and plant height in sweet-waxy maize，but ear diameter，stem diameter and bald pointed length increased.  Reduction drip irrigation fertilization treatment could significantly increase soluble sugar and starch of sweet-waxy maize.  Moreover，the yield and fertilizer productivity were increased by 0.63%-1.40% and 12.67%-102.01%. Moreover， the 30%-40% reduction of fertilizer was the optimal strategy for improving sweet-waxy maize yield and quality under the drip irrigation. 【Conclusion】Using drip irrigation in sweet-waxy maize， fertilizer would be reduced by 30%-40% compared to conventional fertilizer application. The drip irrigation not only could raise the yield， but also improve the quality in the field.