【Objective】The effects of phospholipase D （PLD） inhibitors on storage properties of postharvest longan fruits were studied in order to provide theoretical references for developing new longan preservatives. 【Method】Longan fruits (cv. “Shixia”) were treated by 25 mg/kg PLD inhibitors n-butanol， sec-butanol， lysophosphatidylethanolamine， 2，3-bis-phosphoglycerate， Wortmannin， salbutamol， and sodium cromoglycate， respectively. The postharvest properties of these longan fruits were analyzed during storage at （25±0.5）°C. 【Result】The results showed that the fruits treated with sec-butanol had lower pericarp browning and pulp autolysis， higher soluble solid content，and less fruit weight loss comparing with control. Compared with other PLD inhibitor treatment and the contro1， sec-butanol treatment could better maintain the fruit quality of longan. 【Conclusion】PLD inhibitor sec-butanol could effectively postpone quality deterioration of longan fruits during storage.