【Objective】The present experiment was conducted to study the effect of worm-cast compound based fertilizers on nutrition and growth of Eucalyptus to increase the soil fertility and sustaining growth of Eucalyptus plantations in Guangxi. 【Method】A single factor randomized block experiment was conducted to survey and analyze the growth status of Eucalyptus and the changes in soil properties. Four treatments， viz.， control （100% compound fertilizer）， treatment A （75% compound fertilizer +25% wormcast fertilizer）， treatment B （50% compound fertilizer +50% wormcast fertilizer） and treatment C （25% compound fertilizer + 75% wormcast fertilizer） were used in the current experiment. 【Result】Over the control， macronutrient content in leaves of Eucalyptus were found to be increased in trees treated with A， B and C treatments by 166， 166 and 156%， over control， respectively. The tree height and diameter was found to be increased by 125， 125 and 127%，and 125， 120 and 133%， respectively. Compared to the control， treatment C promoted the best growth of Eucalyptus. Meanwhile， all treatments enhanced the intake of organic matter and nutrient， and alleviated the declining soil pH. 【Conclusion】Adding 25-75% worm-cast compound base fertilizer can significantly promote the growth of Eucalyptus， improve the nutrient distribution in Eucalyptus， increase tree height and diameter， facilitate the absorption of organic matter and nutrient in soil， and alleviate the decrease in soil pH. Therefore， 75% worm-cast base fertilizer shall be applied to reduce the amount of compound fertilizer in Eucalyptus plantations.