【Objective】To build an enriched-flavor special tobacco brand in Chenzhou and develop fertilizers used in tobacco cultivation， the effects of cake fertilizers in combination with special tobacco fertilizer on the growth and development as well as the quality of tobacco leaves were investigated. 【Method】Different ratios of cake organic fertilizer and special fertilizer were applied as base fertilizer and several agronomic traits and leaf quality determining chemical components were measured and analyzed at different growing stages. 【Result】Compared to control， all treatments resulted in 3.01-5.84% increase in plant height and enhancement in effective leaf number from 5.56-20.39%. Further， the sugar/nitrogen ratio in leaves was closer to 10±1， and nitrogen/nicotine ratio in leaves was closer to 1±0.1. 【Conclusion】The combined treatment （T2） of special tobacco base fertilizer （750 kg/ha） and cake organic fertilizer （292 kg/ha） proved to be the best fertilizer pertinent to the improvement of agronomic traits and leaf quality of tobacco.